Grape Seed Extract Prevents H2O2-Induced Chromosomal Damage in Human Lymphoblastoid Cells

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Grape seed extract prevents H(2)O(2)-induced chromosomal damage in human lymphoblastoid cells.

We examined the effects of grape seed extract (GSE) on chromosomal damage in two ways; induction on its own and prevention against treatment of reactive oxygen species (ROS). Chromosomal damage was evaluated by cytokinesis-block micronucleus assay (CBMN) in a human lymphoblastoid cell line, WIL2-NS cells. The GSE was composed of 89% proanthocyanidin with a degree of polymerization ranging from ...

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ژورنال

عنوان ژورنال: Biological and Pharmaceutical Bulletin

سال: 2004

ISSN: 0918-6158,1347-5215

DOI: 10.1248/bpb.27.1459